Leon Battista Alberti (1404–1472) was an architect, artist, musician and mathematician — the model "Renaissance man" — and in 1467 he presented the Pope with a writing device he called Formula: two concentric bronze discs on a common pin. The larger one, Stabilis, holds a capital-letter alphabet; the smaller one, Mobilis, a mixed lowercase alphabet. Turn the inner disc and every letter changes its meaning.
Before Alberti, every cipher known to Europe used one fixed alphabet — and the Arab cryptographers had already shown how to break such ciphers by letter counting. Alberti's disk answers that attack directly: turn the disc and the frequency table of your message no longer applies. The twenty letters of the outer ring were shared across Europe at the time (I, J and U were not yet separate letters, K and W were rarely used), and the digits 1–4 on the ring encoded a second layer: a codebook of 336 phrases that could be superenciphered with the numbers.
Alberti wrote the system down in De Cifris (1467), the first printed book on cryptography. The Latin West slowly absorbed the idea: Johannes Trithemius published the tabula recta — a table of all alphabets laid out in a square — a generation later, and Giovan Battista Bellaso turned the alphabets with an easy-to-remember key phrase. That regularised descendant, misattributed to Blaise de Vigenère, outlived them all — this site covers it under the Vigenère cipher.
The disk itself was superseded, but its two ideas never left cryptography: change the alphabet during the message, and mix the target alphabet instead of merely shifting it. Every rotor machine up to Enigma is Alberti's two discs on a pin, taken seriously.